Paracetamol for the treatment of patent ductus arteriosus in preterm neonates: a systematic review and meta-analysis.

Gianluca TerrinFrancesca ConteMehmet Yekta OncelAntonella ScipionePatrick J McNamaraSinno SimonsRahul SinhaOmer ErdeveKadir S TekgunduzMustafa DoganIrena KesselCathy HammermanE NadirSadik YurttutanBonny JasaniSerdar AlanFrancesco MangusoMario De Curtis

Published in: Archives of disease in childhood. Fetal and neonatal edition (2015)

Efficacy and safety of paracetamol appear to be comparable with those of ibuprofen. These results should be interpreted with caution, taking into account the non-optimal quality of the studies analysed and the limited number of neonates treated with paracetamol so far.

Keyphrases

low birth weight
anti inflammatory drugs
preterm infants
gestational age
case control
newly diagnosed