Evolution of the vertebrate insulin receptor substrate (Irs) gene family.
Ahmad Al-SalamDavid M IrwinPublished in: BMC evolutionary biology (2017)
The Irs gene family originated very early in vertebrate evolution, likely through genome duplications, and in parallel with duplications of other components of the insulin signaling pathway, including insulin and the insulin receptor. While the N-terminal sequences of these proteins are conserved among the paralogs, changes in the C-terminal sequences likely allowed changes in biological function.