The association of germline variants with chronic lymphocytic leukemia outcome suggests the implication of novel genes and pathways in clinical evolution.
Adrián Mosquera OrgueiraBeatriz Antelo RodríguezNatalia Alonso VenceJosé Ángel Díaz AriasNicolás Díaz VarelaManuel Mateo Pérez EncinasCatarina Allegue ToscanoElena María Goiricelaya SecoÁngel Carracedo ÁlvarezJosé Luis Bello LópezPublished in: BMC cancer (2019)
Our results support the existence of inherited conditionants of CLL evolution and points towards genes and pathways that may results useful as biomarkers of disease outcome. More research is needed to validate these findings.