Deep Brain Stimulation Improves Parkinson's Disease-Associated Pain by Decreasing Spinal Nociception.
Veit MyliusJan Harald BaarsKarsten WittDavid BenningerDaniel Ciampi de AndradeGeorg KägiJulien F BallyFlorian BruggerPublished in: Movement disorders : official journal of the Movement Disorder Society (2023)
Dopamine exerts antinociceptive effects on pain in PD at cortical and spinal levels, whereas only cortical effects have been described for DBS, so far. By assessing the nociceptive flexion reflex (NFR) threshold at medication on, and DBS ON and OFF in two patients, we showed that DBS additionally decreases spinal nociception.
Keyphrases
- deep brain stimulation
- parkinson disease
- spinal cord
- neuropathic pain
- obsessive compulsive disorder
- chronic pain
- end stage renal disease
- pain management
- ejection fraction
- chronic kidney disease
- spinal cord injury
- peritoneal dialysis
- prognostic factors
- emergency department
- metabolic syndrome
- patient reported outcomes
- postoperative pain