Characterization of cachexia in the human fibrosarcoma HT-1080 mouse tumour model.

Barbara BernardoStephanie JoaquimJeonifer GarrenMagalie BoucherChristopher HouleBrianna LaCarubbaShuxi QiaoZhidan WuRyan M EsquejoMatthew PeloquinHanna KimDanna M Breen

Published in: Journal of cachexia, sarcopenia and muscle (2020)

The subcutaneous HT-1080 tumour model displays many of the perturbations of energy balance and physical performance described in human cachexia, consistent with the production of key inflammatory factors. Anamorelin was most effective when administered early in disease progression. The HT-1080 tumour model is valuable for studying potential therapeutic targets for the treatment of cachexia.

Keyphrases

endothelial cells
induced pluripotent stem cells
physical activity
oxidative stress
climate change
replacement therapy