Tuneable redox-responsive albumin-hitchhiking drug delivery to tumours for cancer treatment.

Shiwei FuAjay ZhengLukun WangJiuyan ChenBowen ZhaoXiao ZhangVictoria A A McKenzieZixin YangRoger M Leblanc Rajeev Prabhakar Fuwu Zhang

Published in: Journal of materials chemistry. B (2024)

This paper outlines a novel drug delivery system for highly cytotoxic mertansine (DM1) by conjugating to an albumin-binding Evans blue (EB) moiety through a tuneable responsive disulfide linker, providing valuable insights for the development of effective drug delivery systems toward cancer therapy.

Keyphrases

cancer therapy
drug delivery
drug release
metabolic syndrome
insulin resistance
glycemic control
skeletal muscle