Antenatal Dexamethasone Exposure Impairs Vascular Contractile Functions via Upregulating IP3 Receptor 1 and Cav1.2 in Adult Male Offspring.

Ting XuBingyu JiLingjun LiJiahui LeiMeng ZhaoMiao SunZhice XuQinqin Gao

Published in: Hypertension (Dallas, Tex. : 1979) (2022)

Taken together, this study demonstrated that antenatal dexamethasone exposure resulted in vascular adverse outcomes in male offspring that is linked to the increases of IP3R1 and Cav1.2 mediated by epigenetic modifications in the vasculature.

Keyphrases

pregnant women
high fat diet
low dose
high dose
preterm birth
dna methylation
gene expression
skeletal muscle
type diabetes
smooth muscle
insulin resistance
young adults