Different Effects of Knockouts in ALDH2 and ACSS2 on Embryonic Stem Cell Differentiation.

Ryan N SerioChangyuan LuSteven S GrossLorraine J Gudas

Published in: Alcoholism, clinical and experimental research (2019)

ACSS2 knockouts showed no changes in differentiation phenotype, while pluripotency-related transcripts were decreased in ALDH2 knockout ESCs. We demonstrate that AcH increases differentiation-associated mRNAs in ESCs via RARγ.

Keyphrases

cell fate