Bone marrow endothelial progenitor cells activate hepatic stellate cells and aggravate carbon tetrachloride induced liver fibrosis in mice via paracrine factors.
Manali GargSavneet KaurArpita BanikVikash KumarArchana RastogiShiv K SarinAsok MukhopadhyayNirupama TrehanpatiPublished in: Cell proliferation (2017)
Present findings suggest that BM-EPCs migrate to the liver during CCl4-induced liver injury and contribute to fibrosis.
Keyphrases
- liver fibrosis
- bone marrow
- induced apoptosis
- liver injury
- cell cycle arrest
- drug induced
- high glucose
- endothelial cells
- mesenchymal stem cells
- diabetic rats
- high fat diet induced
- oxidative stress
- cell death
- endoplasmic reticulum stress
- signaling pathway
- type diabetes
- metabolic syndrome
- skeletal muscle
- cell proliferation
- pi k akt
- wild type