The VRAC blocker DCPIB directly gates the BK channels and increases intracellular Ca 2+ in melanoma and pancreatic duct adenocarcinoma cell lines.
Paolo ZuccoliniLoretta FerreraAlessia RemiganteCristiana PiccoRaffaella BarbieriSara BertelliOscar MoranPaola GavazzoMichael PuschPublished in: British journal of pharmacology (2022)
. Our findings extend the list of DCPIB effects that should be taken into consideration for future development of DCPIB-based modulators of ion channels and other membrane proteins.