Effects of Maackia amurensis seed lectin (MASL) on oral squamous cell carcinoma (OSCC) gene expression and transcriptional signaling pathways.

Kelly L HamiltonStephanie A SheehanEdward P RetzbachClinton A TimmermanGarret B GianneschiPatrick J TemperaPremalatha BalachandranGary S Goldberg

Published in: Journal of cancer research and clinical oncology (2020)

Taken together, results from this study indicate that MASL decreases activity of JAK-STAT, TGFβ-SMAD, and Wnt-βCTN signaling pathways to inhibit OSCC growth and motility. These data suggest that further studies should be undertaken to determine how MASL may also be used alone and in combination with other agents to treat oral cancer.

Keyphrases

gene expression
signaling pathway
transforming growth factor
epithelial mesenchymal transition
pi k akt
dna methylation
stem cells
cell proliferation
big data
induced apoptosis
escherichia coli
oxidative stress
case control
staphylococcus aureus
cystic fibrosis
artificial intelligence
data analysis