Defining "Complete Cytoreduction" After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS/HIPEC) for the Histopathologic Spectrum of Appendiceal Carcinomatosis.
Carlos A Munoz-ZuluagaMary Caitlin KingVictor S Diaz-SarmientoKimberley StudemanMichelle SittigRyan MacDonaldCarol NierodaKatherin Zambrano-VeraVadim GushchinArmando SardiPublished in: Annals of surgical oncology (2020)
Survival outcomes for CC-0 and CC-1 after CRS/HIPEC are different for HGMCP-S and GCAC but not for LGMCP and HGMCP. In HGCMP-S and GCAC, only CC-0 should be considered a complete cytoreduction and analyzed separately from CC-1. This distinction is key to understand disease behavior, accurately address patient prognosis, and explore new treatment strategies.