Senescence-Associated Secretory Phenotype of Cardiovascular System Cells and Inflammaging: Perspectives of Peptide Regulation.
Vladimir KhavinsonNatalia Sergeevna LinkovaAnastasiia DyatlovaRaisa KantemirovaKirill KozlovPublished in: Cells (2022)
A senescence-associated secretory phenotype (SASP) and a mild inflammatory response characteristic of senescent cells (inflammaging) form the conditions for the development of cardiovascular diseases: atherosclerosis, coronary heart disease, and myocardial infarction. The purpose of the review is to analyze the pool of signaling molecules that form SASP and inflammaging in cells of the cardiovascular system and to search for targets for the action of vasoprotective peptides. The SASP of cells of the cardiovascular system is characterized by a change in the synthesis of anti-proliferative proteins (p16, p19, p21, p38, p53), cytokines characteristic of inflammaging (IL-1α,β, IL-4, IL-6, IL-8, IL-18, TNFα, TGFβ1, NF-κB, MCP), matrix metalloproteinases, adhesion molecules, and sirtuins. It has been established that peptides are physiological regulators of body functions. Vasoprotective polypeptides (liraglutide, atrial natriuretic peptide, mimetics of relaxin, Ucn1, and adropin), KED tripeptide, and AEDR tetrapeptide regulate the synthesis of molecules involved in inflammaging and SASP-forming cells of the cardiovascular system. This indicates the prospects for the development of drugs based on peptides for the treatment of age-associated cardiovascular pathology.
Keyphrases
- induced apoptosis
- cell cycle arrest
- inflammatory response
- cardiovascular disease
- endoplasmic reticulum stress
- heart failure
- dna damage
- immune response
- cell proliferation
- left ventricular
- cell death
- lps induced
- coronary artery disease
- atrial fibrillation
- pseudomonas aeruginosa
- cystic fibrosis
- epithelial mesenchymal transition
- transcription factor
- toll like receptor
- combination therapy
- transforming growth factor
- nuclear factor