Novel monoclonal antibodies against thymidine kinase 1 and their potential use for the immunotargeting of lung, breast and colon cancer cells.

Edwin J VelazquezTaylor D BrindleyGajendra ShresthaEliza E BitterJordan D CressMichelle H TownsendBradford K BergesRichard A RobisonK Scott WeberKim L O'Neill

Published in: Cancer cell international (2020)

The antibodies developed showed potential to be used to detect and target TK1 on the membrane of various tumor cells. The targeting of TK1 in malignant cells using monoclonal antibodies may be a feasible approach for the elimination of high TK1 expressing tumor cells.

Keyphrases

induced apoptosis
human health
cell cycle arrest
oxidative stress
cancer therapy
risk assessment
signaling pathway
protein kinase