Hepatic abnormalities in youth with Turner syndrome.
Isani SinghGillian NoelJennifer M BarkerKathryn C ChatfieldAnna FurnissAmber D KhannaNatalie J NokoffSonali PatelLaura PyleLeena NahataFrancis S ColeChijioke IkomiVaneeta BambaPatricia Y FechnerShanlee M DavisPublished in: Liver international : official journal of the International Association for the Study of the Liver (2022)
Turner Syndrome, a chromosomal condition in which females are missing the second sex chromosome, is often associated with short stature, infertility and cardiac complications. Liver abnormalities are less well described in the literature. In this study, nearly 60% of youth with TS have elevated liver enzymes. Furthermore, patients with TS had a diagnosis of liver disease more often than patients without TS. Our results support the importance of early and consistent liver function screening and of additional research to define mechanisms that disrupt liver function in paediatric TS females.