Vulnerability to acid reflux of the airway epithelium in severe asthma.

Jeanne-Marie PerotinGabrielle WhewayKamran Tariq Adnan AzimRobert A RidleyJonathan A WardJames P R SchofieldClair Barber Peter J Howarth Donna E DaviesRatko Djukanovic

Published in: The European respiratory journal (2022)

By affecting epithelial permeability, GORD may increase exposure of the airway submucosa to allergens and pathogens, resulting in increased risk of inflammation and exacerbations. These results suggest the need for research into alternative therapeutic management of GORD in severe asthma.

Keyphrases

chronic obstructive pulmonary disease
oxidative stress
cystic fibrosis
climate change
endothelial cells
gram negative
antimicrobial resistance