Genomics of ERBB2 -Positive Breast Cancer in Young Women Before and After Exposure to Chemotherapy Plus Trastuzumab.
Marla Lipsyc-SharfEsha JainLaura C CollinsShoshana M RosenbergKathryn J RuddyRulla M TamimiLidia SchapiraSteven E ComeJeffrey M PeppercornVirginia F BorgesEllen WarnerCraig SnowIan E KropDewey KimJakob H WeissJorge Gomez Tejeda ZanudoAnn H PartridgeNikhil WagleAdrienne G WaksPublished in: JCO precision oncology (2023)
CN changes were uncommon. We identified several genes warranting exploration as potential mechanisms of resistance to therapy in this population.
Keyphrases
- positive breast cancer
- epidermal growth factor receptor
- tyrosine kinase
- genome wide
- single cell
- lymph node metastasis
- locally advanced
- metastatic breast cancer
- bioinformatics analysis
- squamous cell carcinoma
- human health
- dna methylation
- gene expression
- stem cells
- risk assessment
- mesenchymal stem cells
- bone marrow
- cell therapy
- transcription factor
- smoking cessation
- replacement therapy