Systemic oxidative stress associates with disease severity and outcome in patients with new-onset or worsening heart failure.
Marie-Sophie L Y de KoningJohanna E EmmensEsteban Romero-HernándezArno R BourgonjeSolmaz AssaSylwia M FigarskaJohn G F ClelandNilesh J SamaniLeong L NgChim C LangMarco MetraGerasimos S FilippatosDirk J van VeldhuisenStefan D AnkerKenneth DicksteinAdriaan A VoorsErik LipsicHarry van GoorPim van der HarstPublished in: Clinical research in cardiology : official journal of the German Cardiac Society (2023)
In patients with new-onset or worsening HF, a lower serum-free thiol concentration, indicative of higher oxidative stress, is associated with increased HF severity and poorer prognosis. Our results do not prove causality, but our findings may be used as rationale for future (mechanistic) studies on serum-free thiol modulation in heart failure. Associations of serum-free thiol concentrations with heart failure severity and outcomes.