Exercise increases caudate dopamine release and ventral striatal activation in Parkinson's disease.

Matthew A SacheliJason L NevaBimal LakhaniDanielle K MurrayNasim VafaiElham ShahinfardCarolyn EnglishSiobhan McCormickKatie DinelleNicole NeilsonJessamyn McKenzieMichael SchulzerDon C McKenzieSilke Appel-CresswellMartin J McKeownLara A BoydVesna SossiA Jon Stoessl

Published in: Movement disorders : official journal of the Movement Disorder Society (2019)

Aerobic exercise alters the responsivity of the ventral striatum, likely related to changes to the mesolimbic dopaminergic pathway, and increases evoked dopamine release in the caudate nucleus. This suggests that the therapeutic benefits of exercise are in part related to corticostriatal plasticity and enhanced dopamine release. © 2019 International Parkinson and Movement Disorder Society.

Keyphrases

prefrontal cortex
uric acid
high intensity
spinal cord
physical activity
metabolic syndrome
parkinson disease
spinal cord injury
drug induced