Systemic Administration of Calea pinnatifida Inhibits Inflammation Induced by Carrageenan in a Murine Model of Pulmonary Neutrophilia.
Bruno Matheus de Campos FacchinJulia Salvan da RosaAna Beatriz Gobbo LuzYeo Jim Kinoshita MoonTamires Cardoso de LimaRosana CasotiMaique Weber BiavattiEduardo Monguilhott DalmarcoTânia Silvia FrödePublished in: Mediators of inflammation (2020)
This study demonstrated that C. pinnatifida presents important anti-inflammatory properties by inhibiting activated leukocytes and protein concentration of the exudate. These effects were related to the inhibition of proinflammatory mediators. The dicaffeoylquinic acids may be partially responsible for these anti-inflammatory properties through the inhibition of nuclear transcription factor kappa B and mitogen-activated protein kinase pathways.