Lithium acts to modulate abnormalities at behavioral, cellular, and molecular levels in sleep deprivation-induced mania-like behavior.

Mutahar AndrabiMuatar Maknoon AndrabiRemesh KunjunniMukesh Kumar SriwastvaSamrat BoseRajesh SagarAchal Kumar SrivastavaRashmi MathurSuman JainVivekanandhan Subbiah

Published in: Bipolar disorders (2019)

Taken together, these results suggest plethora of abnormalities in the brain following REM sleep deprivation, many of these changes in the brain may be target of lithium's mechanism of action.

Keyphrases

resting state
white matter
sleep quality
physical activity
functional connectivity
bipolar disorder
solid state
high glucose
cerebral ischemia
drug induced
depressive symptoms
brain injury
subarachnoid hemorrhage