RNA sequencing identifies global transcriptional changes in peripheral CD4+ cells during active oesophagitis and following epicutaneous immunotherapy in eosinophilic oesophagitis.
Melanie A RuffnerZhe ZhangKelly MaurerAmanda B MuirAntonella CianferoniKathleen E SullivanJonathan M SpergelPublished in: Clinical & translational immunology (2021)
EoE is associated with distinct global transcriptional changes in CD4+ T cells, one feature of which is an IFN response signature. Clinically favorable response to EPIT is likely multifactorial but is associated with a distinct transcriptional profile in peripheral CD4+ cells supporting the hypothesis that EPIT alters peripheral CD4+ responses in EoE patients.
Keyphrases
- induced apoptosis
- gene expression
- cell cycle arrest
- transcription factor
- end stage renal disease
- chronic kidney disease
- ejection fraction
- endoplasmic reticulum stress
- machine learning
- nk cells
- immune response
- oxidative stress
- dendritic cells
- signaling pathway
- peritoneal dialysis
- cell proliferation
- neural network
- heat stress