Effects of protein restriction on insulin-like growth factor (IGF)-1 in men with prostate cancer: results from a randomized clinical trial.

Maria L CagigasGiovanni FioritoBeatrice BertozziAndrius MasedunskasEdda CavaFrancesco SpeltaNicola VeroneseValeria TostiGayathiri RajakumarTiana PelaiaArnold D BullockRobert S FigenshauGerald L AndrioleLuigi Fontana

Published in: Biomarker research (2024)

These findings demonstrate that protein restriction without calorie restriction does not reduce serum IGF-1 concentration or increase IGFBP-1 and IGFBP-3 in men with localized prostate cancer. Further research is needed to identify dietary interventions for safely and effectively reducing IGF-1 in this patient group.

Keyphrases

prostate cancer
binding protein
growth hormone
radical prostatectomy
pi k akt
protein protein
middle aged
amino acid
case report
weight loss
small molecule
signaling pathway
cell proliferation