Elutriated lymphocytes for manufacturing chimeric antigen receptor T cells.

David F StroncekDaniel W LeeJiaqiang RenMarianna SabatinoSteven HighfillHanh KhuuNirali N ShahRosandra N KaplanTerry J FryCrystal L Mackall

Published in: Journal of translational medicine (2017)

Enrichment of PBMC concentrates for lymphocytes using elutriation increased the quantity of GD2-CAR T cells produced. These results provide further evidence that CAR T cell expansion is inhibited by monocytes and granulocytes.

Keyphrases

peripheral blood
dendritic cells
immune response