Putative protective role of autoantibodies against the insulin-like growth factor-1 receptor in Graves' Disease: results of a pilot study.

G LanzollaD RicciF NicolìE SabiniA SframeliA BrancatellaM MantuanoG R DottoreI BucciM FigusM NardiF LatrofaC MarcocciMichele Marinò

Published in: Journal of endocrinological investigation (2020)

IGF-1RAbs appear to be greater in patients with GD without GO compared with those with GO, suggesting a putative protective role of IGF-1RAbs on the development of GO, in line with the beneficial effects of Teprotumumab on GO. The inverse correlation between IGF-1RAbs and TRAbs 6 months after radioiodine may reflect antigen spreading and/or GC treatment.

Keyphrases

growth hormone
binding protein
pi k akt
systemic lupus erythematosus
signaling pathway
gas chromatography
replacement therapy
liquid chromatography