A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations.
Heming WangPavithra NagarajanThomas WinklerAmy R BentleyClint MillerAldi KrajaKaren SchwanderSongmi LeeWenyi WangMichael R BrownJohn MorrisonAyush GiriJeffrey O'ConnellTraci BartzLisa de Las FuentesValborg GudmundsdottirXiuqing GuoSarah E HarrisZhijie HuangMart KalsMinjung KhoChristophe M LefèvreJian'an LuanLeo-Pekka LyytikainenMassimo ManginoY MilaneschiNicholette D D AllredVarun RaoRainer RauramaaBotong ShenStefan StadlerQuan SunJingxian TangSébastien ThériaultAdriaan van der GraafPeter J van der MostYujie WangStefan WeissKenneth WestermanQian YangTabara YasuharuWei ZhaoWanying ZhuDrew AltschulMd Abu Yusuf AnsariPramod AnuguAnna Argoty-PantojaMichael ArztHugues AschardJohn Richard AttiaLydia BazzanoMax BreyerJennifer BrodyBrian E CadeHung-Hsin ChenYii-Der Ida ChenZekai ChenPaul S de VriesLatchezar DimitrovAhn DoJiawen DuCharles DupontTodd EdwardsMichele EvansTariq FaquihStephan FelixSusan Fisher-HochJames FloydMariaelisa GraffCharles C GuDongfeng GuKristen HairstonAnthony HanleyIris M HeidSami HeikkinenHeather M HighlandMichelle HoodMika KähönenCarrie Karvonen-GutierrezTakahisa KawaguchiSetoh KazuyaKelly TanikaPirjo KomulainenDaniel LevyHenry LinPeter Y LiuPedro Marques-VidalJoseph B McCormickHao MeiJames MeigsCristina MenniKisung NamIlja Maria NolteNatasha PachecoLauren PettyHannah PolikowskyMichael A ProvinceBruce M PsatyLaura RaffieldOlli RaitakariStephen S RichRenata RihaLorenz RischMartin RischEdward Ruiz-NarvaezRodney J ScottColleen SitlaniJennifer A SmithTamar SoferMaris Teder-LavingLinus VölkerPeter VollenweiderGuanchao WangKo Willems van DijkOtis WilsonRui XiaJie YaoKristin YoungRuiyuan ZhangXiaofeng ZhuJennifer E BelowCarsten BögerDavid ConenSimon R CoxMarcus DörrMary F FeitosaErvin FoxNora FranceschiniSina A GharibVilmundur G GudnasonSioban HarlowJiang HeElizabeth HollidayZoltan KutalikTimo LakkaDeborah A LawlorSeunggeun LeeTerho LehtimäkiChangwei LiChing-Ti LiuReedik MägiFumihiko MatsudaAlanna C MorrisonBrenda W J H PenninxPatricia A PeyserJerome I RotterHarold SniederT SpectorLynne WagenknechtNicholas J WarehamAlan B ZondermanKari E NorthMyriam FornageAdriana HungAlisa ManningW GaudermanHan ChenPatricia MunroeDabeeru RaoDiana van HeemstSusan RedlineRaymond NoordamPublished in: Research square (2024)
Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we carried out genome-wide cross-population gene-by-short-sleep and long-sleep duration interaction analyses for three blood pressure traits (systolic, diastolic, and pulse pressure) in 811,405 individuals from diverse population groups. We discover 22 novel gene-sleep duration interaction loci for blood pressure, mapped to 23 genes. Investigating these genes' functional implications shed light on neurological, thyroidal, bone metabolism, and hematopoietic pathways that necessitate future investigation for blood pressure management that caters to sleep health lifestyle. Non-overlap between short sleep (12) and long sleep (10) interactions underscores the plausible nature of distinct influences of both sleep duration extremes in cardiovascular health. Several of our loci are specific towards a particular population background or sex, emphasizing the importance of addressing heterogeneity entangled in gene-environment interactions, when considering precision medicine design approaches for blood pressure management.
Keyphrases
- blood pressure
- genome wide
- dna methylation
- hypertensive patients
- copy number
- heart rate
- physical activity
- sleep quality
- genome wide identification
- mental health
- public health
- metabolic syndrome
- gene expression
- blood glucose
- healthcare
- brain injury
- risk assessment
- weight loss
- climate change
- depressive symptoms
- skeletal muscle
- bone loss