Remdesivir resistance in transplant recipients with persistent COVID-19.
John I HoganRalf DuerrDacia DimartinoChristian MarierSarah E HochmanSapna MehtaGuiqing WangAdriana HeguyPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)
New mutations conferring resistance to SARS-CoV-2 therapeutics have important clinical implications. We describe the first cases of an independently acquired V792I RNA-dependent RNA polymerase mutation developing in renal transplant recipients after remdesivir exposure. Our work underscores the need for augmented efforts to identify concerning mutations and address their clinical implications.