A new [7.7]paracyclophane from Vietnamese marine snail Planaxis sulcatus (Born, 1780).

Nguyen Van ThanhNguyen Phuong ThaoNguyen Viet PhongNguyen Xuan CuongNguyen Hoai NamChau Van Minh

Published in: Natural product research (2018)

A new [7.7]paracyclophane (1), together with eight known compounds (2-9), were isolated from a MeOH extract of the sea snail Planaxis sulcatus (Born, 1780). Their structures were elucidated by HR-ESI-MS and NMR techniques as well as comparison with those reported in literatures. The absolute configuration of metabolite 1 was determined using ECD spectroscopy. Among nine compounds, 1 exhibited significant cytotoxicity toward all eight cancer cells tested with IC50 values between 1.81 and 3.80 µg/mL.[Figure: see text].

Keyphrases

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