The pluripotency factor NANOG contributes to mesenchymal plasticity and is predictive for outcome in esophageal adenocarcinoma.
Amber P van der ZalmMark P G DingsPaul ManoukianHannah BoersmaReimer JanssenPeter BaileyJan KosterDanny ZwijnenburgRichard VolckmannSanne BootsmaCynthia WaasdorpMonique van MourikDionne BlangéTom van den EndeCésar I OyarceSarah DerksAafke CreemersEva A EbbingGerrit K J HooijerSybren L MeijerMark Ivo van Berge HenegouwenJan Paul MedemaHanneke W M van LaarhovenMaarten F BijlsmaPublished in: Communications medicine (2024)
In conclusion, NANOG is a key transcription factor in mesenchymal plasticity in EAC and a promising predictive marker for outcome.