mTOR-Notch3 signaling mediates pulmonary hypertension in hypoxia-exposed neonatal rats independent of changes in autophagy.

Julijana IvanovskaSparsh ShahMathew J WongCrystal KantoresAmish JainMartin PostBehzad YeganehRobert P Jankov

Published in: Pediatric pulmonology (2017)

mTOR-Notch3 signaling plays a critical role in experimental chronic neonatal PHT. Inhibition of autophagy did not suppress Notch signaling and had no effect on markers of chronic PHT.

Keyphrases

pulmonary hypertension
cell death
endoplasmic reticulum stress
signaling pathway
cell proliferation
oxidative stress
pulmonary artery
endothelial cells
pulmonary arterial hypertension
drug induced