Multimodal testing reveals subclinical neurovascular dysfunction in prediabetes, challenging the diagnostic threshold of diabetes.
Varo KirthiKate I ReedKomeil AlattarBenjamin P ZuckermanCatey BuncePaul NderituUazman AlamBronagh ClarkeScott C HauFatima Al-ShibaniIoannis N PetropoulosRayaz Ahmed MalikTheodoros PissasChristos BergelesPrashanth R J VasDavid HopkinsTimothy L JacksonPublished in: Diabetic medicine : a journal of the British Diabetic Association (2022)
The glucose threshold for the diagnosis of diabetes is based on emergent retinopathy on fundus examination. We show that both abnormal retinal neurovascular structure (OCT-A) and function (ERG) may precede retinopathy in prediabetes, which require confirmation in larger, adequately powered studies.