Thyroid hormones T3 and T4 regulate human luteinized granulosa cells, counteracting apoptosis and promoting cell survival.

V Di PaoloC MangialardoC ZacàM BarberiE SereniA BoriniM CentanniG CoticchioC Verga-FalzacappaRita Canipari

Published in: Journal of endocrinological investigation (2020)

From the present study, THs emerge as potent anti-apoptotic agents in hGL cells. This effect is achieved by inhibiting the apoptosis signalling pathway of BAX and caspase-3, while maintaining active the PI3K/AKT pathway.

Keyphrases

cell cycle arrest
induced apoptosis
cell death
endoplasmic reticulum stress
oxidative stress
signaling pathway
pi k akt
endothelial cells
insulin resistance