Thalamic Dorsomedial Nucleus Free Water Correlates with Cognitive Decline in Parkinson's Disease.

Thomas J GuttusoDaniel SiricaDuygu TosunRobert ZivadinovOfer PasternakDaniel WeintraubFrancesca BaglioNiels P Bergsland

Published in: Movement disorders : official journal of the Movement Disorder Society (2021)

Thalamic DMN FW is a promising cognition progression biomarker in early PD that may assist in identifying cognition protective therapies in clinical trials. FW is a robust assessment modality for these outcomes. © 2021 International Parkinson and Movement Disorder Society.

Keyphrases

cognitive decline
mild cognitive impairment
deep brain stimulation
clinical trial
white matter
prefrontal cortex
skeletal muscle
open label
glycemic control