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Assembly of spirocyclic pyrazolone-pyrrolo[4,3,2- de ]quinoline skeleton via cascade [1,5] hydride transfer/cyclization by C(sp 3 )-H functionalization.

Xin XieHe HuangYu FanYuan LuoQiwen PangXiang LiWei Huang
Published in: Organic & biomolecular chemistry (2023)
Herein, a highly efficient, scalable, and cascade [1,5] hydride transfer/cyclization method for constructing unique spirocyclic pyrazolone-pyrrolo[4,3,2- de ]quinoline structures via C(sp 3 )-H functionalization is achieved, using pyrazolones and oxindoles attached to C4 amines. This strategy represents a limited approach utilizing C-H activation to construct spirocyclic pyrazolone scaffolds with moderate to excellent reaction performance.
Keyphrases
  • highly efficient
  • molecular docking
  • electron transfer
  • high resolution
  • high intensity
  • tissue engineering
  • molecular dynamics simulations