Necrostatin-1 supplementation enhances young porcine islet maturation and in vitro function.
Hien LauNicole CorralesMichael AlexanderMohammad Rezaa MohammadiShiri LiAlexandra M SminkPaul de VosJonathan R T LakeyPublished in: Xenotransplantation (2019)
This study underlines the importance of necroptosis in islet cell death after isolation and demonstrates the novel effects of Nec-1 to increase islet insulin content, enhance pancreatic endocrine cell development, facilitate GLUT2 upregulation in beta cells, and augment insulin secretion. Nec-1 supplementation to culture media significantly improves islet quality prior to xenotransplantation.