Co-transplantation with adipose-derived cells to improve parathyroid transplantation in a mice model.

Qiuxia CuiDan ZhangDeguang KongJianing TangXing LiaoQian YangJiangbo RenYan GongGao-Song Wu

Published in: Stem cell research & therapy (2020)

Adipose-derived cells, including ADSCs and SVFs, improve parathyroid transplantation survival via promoting angiogenesis through EYA1-regulating angiogenetic factors in vitro and in vivo. Our studies proved an effective method to improve the parathyroid autotransplantation, which is promising for clinical patients with hypoparathyroidism when parathyroid glands were accidentally injured, removed, or devascularized.

Keyphrases

induced apoptosis
cell cycle arrest
cell therapy
endoplasmic reticulum stress
stem cells
signaling pathway
endothelial cells
cell death
vascular endothelial growth factor
mesenchymal stem cells
insulin resistance