Fanconi anemia and hematopoietic stem cell transplant as risk factors for oral squamous cell carcinoma: A case report with a 12-year follow-up.
Larissa Fernanda Dos Santos Lima MacedoCarina DomaneschiLucyene Miguita LuizMaria Paula Siqueira de Melo PeresJuliana Bertoldi FrancoPublished in: Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry (2021)
Fanconi anemia is a rare disorder resulting from defects in genes responsible for DNA damage responses. It is characterized by congenital anomalies, aplastic anemia, and a predisposition to cancer. Currently, hematopoietic stem cell transplant (HSCT) is the only curative treatment available for bone marrow failure; however, HSCT increases oral squamous cell carcinoma (OSCC) risk. Here we report the case of a patient diagnosed with Fanconi anemia in childhood who was treated with HSCT and later diagnosed with multiple OSCCs during a 12-year follow-up. Despite multiple surgical interventions and radiotherapy regimens, the patient`s health deteriorated. Management of individuals with Fanconi anemia is challenging and must be provided by a multidisciplinary healthcare team to ensure better staging, treatment planning, and coordination.
Keyphrases
- hematopoietic stem cell
- iron deficiency
- chronic kidney disease
- healthcare
- bone marrow
- dna damage
- mental health
- oxidative stress
- case report
- social media
- public health
- palliative care
- young adults
- physical activity
- early stage
- quality improvement
- locally advanced
- papillary thyroid
- acute myeloid leukemia
- mesenchymal stem cells
- gene expression
- genome wide
- rectal cancer
- radiation induced
- health insurance
- squamous cell
- transcription factor