First-line PARP inhibitor maintenance treatment in ovarian carcinoma for older adult women: a review of the current literature.
Maria Masvidal HernandezSara Cros CostaCarmen SalvadorAlicia Quilez CutillasMaria-Pilar Barretina-GinestaAlmudena Cotes SanchísPublished in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2024)
Ovarian cancer (OC) is the leading cause of death in women with gynecological cancers. Its diagnosis is more likely in advanced ages, with the older population being the most seen in consultations. Poly(ADP-ribose) inhibitors (PARPi) have changed OC clinical practice and evolution, showing great benefit. However, there is a lack of evidence of PARPi in elderly population that can impact the therapeutic decision and the safety/efficacy. It is necessary to avoid age as limiting factor in PARPis prescription. We conducted a review of the most relevant randomized phase III trials of maintenance PARPi after first-line treatment of advanced OC. We observed the lack of a single criterion for considering older patients, varying among trials. There is a benefit of PARPis in different populations. However, PARPi effect on quality of life is not reported, something of great relevance considering their vulnerability. Measures are needed to benefit older patients to better adapt PARPi treatment.
Keyphrases
- phase iii
- open label
- middle aged
- community dwelling
- double blind
- clinical practice
- systematic review
- placebo controlled
- physical activity
- climate change
- polycystic ovary syndrome
- dna damage
- type diabetes
- pregnant women
- primary care
- combination therapy
- oxidative stress
- insulin resistance
- adipose tissue
- skeletal muscle
- study protocol