Pharmacogenetic impact of UGT1A1 polymorphisms on pulmonary neuroendocrine tumours treated with metronomic irinotecan-based chemotherapy in Chinese populations.

Xu Ma Sen Han Ying Liu Jing-Tao Liu Jian Fang Yan-Hua Zhang

Published in: The Journal of pharmacy and pharmacology (2020)

The impact of UGT1A1 polymorphisms varies in different irinotecan-based chemotherapies. UGT1A1*6 and UGTA1A*28 were useful for the prediction of irinotecan-related severe toxicity in Chinese PNT patients treated with metronomic IBC.

Keyphrases

pulmonary hypertension
oxidative stress
early onset
locally advanced
squamous cell carcinoma
drug induced
radiation therapy
genetic diversity