Quantum yield enhancement of firefly bioluminescence with biomolecular condensates.

Ryo NishiharaYoshiki KiharaKazuki NiwaMasahiro MimuraShunsuke Tomita Ryoji Kurita

Published in: Chemical communications (Cambridge, England) (2022)

The enzymatic luminescence reactions of fireflies are accelerated in the presence of biomolecular condensates comprising a positively charged peptide and ATP. We revealed that this acceleration is caused by the enrichment of reaction elements, local pH changes, and promotion of inhibitory intermediate dissociation, improving the bioluminescence quantum yield by approximately 10%.

Keyphrases

energy transfer
quantum dots
electron transfer
hydrogen peroxide
single cell
molecular dynamics
nitric oxide