Method considerations and study protocol for a Nordic multi-centre prospective study on outcomes in rare paediatric epilepsy surgery subgroups.
Jesper ReinholdsonKristina MalmgrenJohn Eric ChaplinIngrid OlssonTove HallböökPublished in: Acta paediatrica (Oslo, Norway : 1992) (2023)
Epilepsy surgery is a therapeutic option for selected children with drug-resistant epilepsy. Children who are surgical candidates have a high prevalence of neurodevelopmental comorbidities. There is a lack of adequately sized prospective studies in a number of rare surgical subgroups, especially of outcome domains such as cognitive level and health-related quality-of-life. In this article, we describe method considerations and a study protocol for a Nordic population-based multi-centre follow-up programme covering seizure as well as non-seizure outcomes in children aged <4 years undergoing resective epilepsy surgery and children aged ≤18 years undergoing hemispherotomy, callosotomy or surgery for hypothalamic hamartoma.
Keyphrases
- minimally invasive
- drug resistant
- coronary artery bypass
- young adults
- multidrug resistant
- emergency department
- intensive care unit
- temporal lobe epilepsy
- type diabetes
- clinical trial
- acinetobacter baumannii
- metabolic syndrome
- percutaneous coronary intervention
- skeletal muscle
- insulin resistance
- acute coronary syndrome
- pseudomonas aeruginosa
- weight loss
- glycemic control
- case control
- double blind