Association of High-Dose Ibuprofen Use, Lung Function Decline, and Long-Term Survival in Children with Cystic Fibrosis.
Michael W KonstanDonald R VanDevanterGregory S SawickiDavid J PastaAimee J ForemanEvgueni A NeimanWayne J MorganPublished in: Annals of the American Thoracic Society (2019)
In a propensity-score matched cohort study of children with cystic fibrosis, we observed an association between high-dose ibuprofen use and both slower lung function decline and improved long-term survival. These results are consistent with the hypothesis that treatment-associated reduction of lung function decline in children with cystic fibrosis leads to improved survival.