OVOL2 impairs RHO GTPase signaling to restrain mitosis and aggressiveness of Anaplastic Thyroid Cancer.

Mila GugnoniGloria ManzottiEmanuele VitaleElisabetta SautaFederica TorricelliFrancesca ReggianiMariaelena PistoniSimonetta PianaAlessia Ciarrocchi

Published in: Journal of experimental & clinical cancer research : CR (2022)

Collectively, these data describe the role of OVOL2 in ATC and uncover a novel function of this TF in inhibiting the RHO GTPase pathway interlacing its effects on EMT, cytoskeleton dynamics and mitosis.

Keyphrases

protein kinase
epithelial mesenchymal transition
smooth muscle
electronic health record
signaling pathway
big data
machine learning
data analysis
deep learning