Chemically modified peanut extract shows increased safety while maintaining immunogenicity.

Hanneke P M van der KleijHans J M WarmenhovenRonald van ReeSerge A VersteegRaymond H H PietersStephen C DreskinAndré C KnulstEls van HoffenDirk Jan E OpsteltenStef J KoppelmanJoost J Smit

Published in: Allergy (2018)

In our studies, an Al(OH)3 adsorbed MPE showed reduced allergenicity compared to unmodified PE, while the efficacy of immunotherapy is maintained. The preclinical data presented in this study supports further development of modified peanut allergens for IT.

Keyphrases

oxidative stress
electronic health record
big data
stem cells
mesenchymal stem cells
bone marrow
deep learning