Crosslinking catalytic hairpin assembly for high-contrast imaging of multiple mRNAs in living cells.

Du-Juan HuangTing CaoZhi-Mei HuangZhen-Kun WuLi-Juan TangJian-Hui Jiang

Published in: Chemical communications (Cambridge, England) (2019)

A novel DNA nanotetrad mediated crosslinking catalytic hairpin assembly (CCHA) is reported to generate clumps of cross-linked mesh products for high-contrast and simultaneous imaging of multiple mRNAs in living cells.

Keyphrases

living cells
fluorescent probe
single molecule
high resolution
magnetic resonance
circulating tumor
magnetic resonance imaging
computed tomography
cell free
genome wide analysis