Development and Validation of a Simple Method for Simultaneously Measuring the Concentrations of BCR-ABL and Bruton Tyrosine Kinase Inhibitors in Dried Blood Spot (DBS): A Pilot Study to Obtain Candidate Conversion Equations for Predicting Plasma Concentration Based on DBS Concentration.
Yuji MukaiTatsunari YoshidaTakeshi KondoJun MiuraNobuo InotsumeTakaki TodaPublished in: Therapeutic drug monitoring (2022)
A simple method for the simultaneous determination of BCR-ABL and Bruton TKI concentrations in DBS was developed and validated. Owing to the small clinical sample size, further clinical validation is needed to determine the predictive performance of EPCs for the 6 TKIs.
Keyphrases
- chronic myeloid leukemia
- tyrosine kinase
- simultaneous determination
- deep brain stimulation
- liquid chromatography tandem mass spectrometry
- acute lymphoblastic leukemia
- epidermal growth factor receptor
- high performance liquid chromatography
- tandem mass spectrometry
- liquid chromatography
- mass spectrometry
- solid phase extraction
- ms ms