TTP-mediated regulation of mRNA stability in immune cells contributes to adaptive immunity, immune tolerance and clinical applications.
Yiwei ZhangJian ZhouZhiyuan WeiHui DongDi YangYuanyu DengJiahui LiSaiyu ShiYi SunHuimin LuJizhao YuanBing NiYuzhang WuYi TianChao HanPublished in: RNA biology (2021)
Dendritic cells (DCs) form a sentinel network to induce protective immunity against pathogens or self-tolerance. mRNA stability is an important part of the post-transcriptional regulation (PTR) that controls the maturation and function of DCs. In this review, we summarize the effects of TTP-mediated regulation of mRNA stability in DCs, focusing on DC maturation and antigen presentation, T cell activation and differentiation, immune tolerance and inflammation. We also discuss the potential DC-based immune treatment for HIV+ patients through regulation of mRNA stability. This review proposes the regulation of mRNA stability as a novel immune therapy for various inflammatory diseases, such as arthritis and dermatitis.
Keyphrases
- dendritic cells
- binding protein
- end stage renal disease
- oxidative stress
- chronic kidney disease
- newly diagnosed
- ejection fraction
- antiretroviral therapy
- hiv infected
- rheumatoid arthritis
- hepatitis c virus
- human immunodeficiency virus
- regulatory t cells
- hiv positive
- human health
- patient reported outcomes
- atopic dermatitis