Medermycin-Type Naphthoquinones from the Marine-Derived Streptomyces sp. XMA39.
Yong-Jun JiangDa-Shan ZhangHao-Jian ZhangJia-Qi LiWan-Jing DingCheng-Dong XuZhong-Jun MaPublished in: Journal of natural products (2018)
Four new medermycin-type naphthoquinones, strepoxepinmycins A-D (1-4), and one known compound, medermycin (5), were identified from Streptomyces sp. XMA39. Their structures were elucidated by analysis of HRESIMS, 1D and 2D NMR spectroscopic data, and ECD calculations. Among these compounds, strepoxepinmycin A (1) represents a rare 5,10-oxepindione ring system typically formed by a Baeyer-Villiger oxidation, and strepoxepinmycin B (2) is an isolation artifact derived from 1. Bioactivity evaluations of these compounds showed that compounds 3 and 4 exhibited cytotoxicity against HCT-116 and PC-3 cancer cell lines and 4 exhibited moderate inhibition of ROCK 2 protein kinase. In addition, all of the new compounds showed antibacterial activity against Escherichia coli and methicillin-resistant Staphylococcus aureus and antifungal activity against Candida albicans.
Keyphrases
- candida albicans
- methicillin resistant staphylococcus aureus
- escherichia coli
- biofilm formation
- protein kinase
- staphylococcus aureus
- magnetic resonance
- hydrogen peroxide
- squamous cell carcinoma
- high intensity
- magnetic resonance imaging
- mass spectrometry
- molecular dynamics simulations
- young adults
- molecular dynamics
- nitric oxide
- pseudomonas aeruginosa
- deep learning
- cell proliferation
- klebsiella pneumoniae
- multidrug resistant
- silver nanoparticles
- lymph node metastasis
- dual energy