Acute Pancreatitis Increases the Risk of Gastrointestinal Cancer in Type 2 Diabetic Patients: A Korean Nationwide Cohort Study.
Young Hoon ChoiWoo Hyun PaikDong Kee JangMin Kyu KimJi-Kon RyuYong-Tae KimKyungdo HanSang Hyub LeePublished in: Cancers (2022)
The association between acute pancreatitis (AP) and gastrointestinal cancers in diabetic patients is currently not well understood. The study aim was to investigate the association between AP and gastrointestinal cancers in diabetic patients. Data from the Korean National Health Insurance Service database were analyzed. Participants with diabetes who underwent a health examination between 2009 and 2012 were followed up till December 2018. The primary outcome was the occurrence of gastrointestinal cancer. A total of 2,263,184 patients were included in the final analysis. Patients with a history of AP ( n = 2390) were found to have a significantly higher risk of gastrointestinal cancer, except for esophageal cancer, as follows: gastric cancer (aHR = 1.637, 95% CI: 1.323-2.025), colorectal cancer (aHR = 2.183, 95% CI: 1.899-2.51), liver cancer (aHR = 2.216, 95% CI: 1.874-2.621), pancreatic cancer (aHR = 4.558, 95% CI: 4.078-5.095), bile duct cancer (aHR = 3.996, 95% CI: 3.091-5.269), and gallbladder cancer (aHR = 2.445, 95% CI: 1.459-4.099). The history of AP is associated with the increased risk of gastrointestinal cancer in diabetic patients. It is necessary to investigate the history of AP and more actively recommend screening for gastrointestinal cancers in such patients.
Keyphrases
- papillary thyroid
- end stage renal disease
- squamous cell
- health insurance
- ejection fraction
- chronic kidney disease
- type diabetes
- healthcare
- mental health
- prognostic factors
- cardiovascular disease
- lymph node metastasis
- emergency department
- public health
- patient reported outcomes
- insulin resistance
- machine learning
- adipose tissue
- patient reported
- climate change
- deep learning
- artificial intelligence
- affordable care act
- human health