A CuS- and BODIPY-loaded nanoscale covalent organic framework for synergetic photodynamic and photothermal therapy.

Xiao-Jie DongWen-Yan LiQun Guan Yan-An Li Yu-Bin Dong

Published in: Chemical communications (Cambridge, England) (2022)

Herein, we report an inorganic photothermal agent, CuS- and an organic photosensitizer, BODIPY-loaded composite nanoscale COF material via a stepwise post-synthetic modification. The obtained CuS@COF-BDP can be a dual-modal therapeutic agent to highly inhibit MCF-7 tumor cell proliferation due to its efficient singlet oxygen generation and photothermal conversion abilities.

Keyphrases

cancer therapy
drug delivery
photodynamic therapy
cell proliferation
water soluble
fluorescent probe
living cells
atomic force microscopy
drug release
breast cancer cells
cell cycle
single molecule
pi k akt
high speed
high resolution
signaling pathway